Van de Ven Brace Halts The Toffees' Run at Brand New Stadium
The Dutch defender became the initial backline player to score twice in a Premier League match for Spurs since the Belgian defender in spring 2013.
At a glance
Micky Van de Ven heads home twice in opening period
The home side's Jake O'Brien has goal disallowed after video check
Senegalese midfielder nets final goal in 89th minute
This loss is Everton's initial at their new ground
The Tottenham defender found the net on two occasions as Spurs prolonged their unbeaten run on the road in the top division and delivered the Toffees their first defeat at their new home.
Everton were undefeated in their last five matches at their recently opened stadium at the dockside location, having departed their historic home behind after 133 years at the end of the previous campaign.
But Tottenham's leader Van de Ven struck on two occasions from set-pieces in the opening 45 minutes to place their strong form at risk, and they were unable to turn it around before Pape Matar Sarr - assisted by ex-Everton forward the Brazilian - nodded in a third to put the game to bed.
Jake O'Brien believed he had equalized the tally five minutes after Van de Ven's first goal, directing a powerful header past the Spurs keeper from an set-piece.
Beto, meanwhile, failed to convert a number of chances, while Vicario made a series of excellent stops to ensure Tottenham went five away games unbeaten in the English top flight.
But the VAR intervened, instructing Craig Pawson to review the goal on the pitchside monitor and the official ruled that Jack Grealish and Iliman Ndiaye were in an illegal position and had interfered with the Spurs keeper.
This victory moves the manager's team up to third in the division, five points off local foes and leaders the Gunners.
Everton remain in 14th position and sit six points ahead of the drop zone.
Spurs breakdown: Van de Ven excels in duties at each end of pitch
After a uninspiring midweek display in the European competition against the French side, where they mustered a only two shots on goal, the manager chose Randal Kolo Muani in attack instead of ex-Everton forward Richarlison.
The new arrival was unable to influence the game before being replaced for the substitute after 60 minutes on the field, but it turns out he wasn't needed in the end.
Centre-back Van de Ven transformed into an attacking force to be feared.
Tottenham's first goal came from a cleverly executed set-piece play, with the midfielder directing the ball back across the face of goal for an free Van de Ven to head home.
And the captain - filling in as captain in the Argentine's absence - notched his second in added time as he rose above the England keeper to head home.
The Dutchman was just as outstanding in defence, partnering well with Kevin Danso as the pair dealt superbly with the 34 crosses sent their way by the opposition.
Toffees breakdown: Toffees missing finishing touch
Everton's new home had been a happy hunting ground, but it appears the freshness may have faded slightly and supporters headed to the exits after Sarr's third for Tottenham.
The break in Everton's winning streak at home won't be a major concern for David Moyes, but their striker situation are.
The forward and Thierno Barry - the Everton's pair of recognised centre-forwards - had scored just a single goal between them before the weekend's match.
And they were failed to add to that poor tally on a wet and gloomy night on in Liverpool.
Beto's form was summed up when he opted to overhead kick a clear chance from near the goal, even with having space and time to readjust for a more conventional attempt that would have tested Vicario.
Barry, as well, was unable to make an impact after coming on for the starter in the 65th minute.
It wasn't for a shortage of opportunity. The majority of Everton's attacks came through Grealish and the forward, who tirelessly whipped dangerous balls into the Spurs penalty area.
Upcoming fixtures for both teams?
The Toffees: Moyes' men travel to Sunderland in the Premier League on Monday, 3 November at 20:00 GMT.
Spurs: The London club travel to St James' Park on late October for their next round League Cup match against Newcastle.